Crocin Possesses Excellent Hepatoprotective Effects Against Acetaminophen-Induced Hepatotoxicity in Mice

Background: Acetaminophen (APAP) is a common analgesic and antipyretic medicine that can lead to acute liver injury at high doses. Crocin, Crocus sativus’ ingredient, has potent antioxidant effects. Objectives: This study examined the protective effects of crocin against APAP-induced oxidative stress in mice. Methods: In this study, 56 mice were randomly divided into seven groups (n = 8 per group), including negative (normal saline, 10 mL/kg) positive (oral normal saline for five days + single dose APAP (300 mg/kg) on day 6th) control groups. The third group (NAC) received up days, 6th day, immediately after administration acetaminophen, NAC (50 mg/kg). Groups fourth sixth respectively 12.5, 25, 50 mg/kg (orally six days), followed by day. last days. Then 24 h injection, animals sacrificed, samples collected biochemical histopathological evaluations. Results: levels ALT, AST, MDA increased, activity CAT, GSH, GPX decreased APAP-treated compared group. groups, serum increased GPX. Histopathological evaluations confirmed above findings. Conclusions: According our results, it seems effect acetaminophen-induced toxicity be used as therapeutic agent treat hepatotoxicity.